Endocrine Abstracts

PCOS is associated with insulin resistance and dyslipidaemia. Adiponectin receptors (Adipo-R1, Adipo-R2) are expressed in human myotubes. Their mRNA levels were found to be correlated with insulin and circulating triglycerides.The aims of this study, were to investigate the expression of adiponectin and its receptors in adipose tissue from normal and PCOS women (Ethical approval was obtained from the University Hospitals Coventry & Warwickshire NHS T...

The adrenal gland is implicated in energy homeostasis, and dysfunction of this gland contributes to a variety of metabolic disorders including the development of hypertension, diabetes, osteoporosis, and obesity. Recently, adipokines have been implicated in adrenal function. Adiponectin, an adipokine, with insulin sensitising and anti-inflammatory properties, exerts its effects by activating two distinct seven transmembrane domain receptors, adiponectin-R1 (adipoR1) and -R2 (a...

Adiponectin has been shown to modulate angiogenesis and tumour cell behaviour. Breast and endometrial cancer patients have significantly decreased serum adiponectin levels, which may be important in such hormone-dependent cancers. Prostate cancer is another hormone-dependent cancer. Adiponectin orchestrates its actions by activating two seven-transmembrane receptors, adiponectin-R1 (adipo-R1) and adiponectin-R2 (adipo-R2). In this study we aim to determine adipo-R1/R2 expressi...